Lack of mechanical and thermal allodynia, and thermal hyperalgesia induced by peripheral neuropathic pain in NOS2 knockout mice
نویسندگان
چکیده
Background Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, hyperalgesia and allodynia. Several works have demonstrated that selective NOS2 inhibitors might reverse the hypersensitivity to pain induced by neuropathy [1,2]. Although these studies suggest a potential role of NOS2 in the modulation of neuropathic pain, the exact involvement of NOS2 in the development of peripheral neuropathic pain remains unclear. The aim of this study is to investigate the involvement of nitric oxide synthesized by NOS2 in the development and expression of neuropathic pain after total sciatic nerve injury.
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